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Mutation Query
Allele 1:E1163G
Allele 2: E1143G, W748S

Allelic information known

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Residue W748
Cluster assignment:
Cluster 5
Cluster description:Putative protein-protein interactions
Subcluster:5B (residues 737-749)
Subcluster description:Located in the periphery of the IP subdomain of the spacer domain, distant from the DNA binding channel
POLG domain:Spacer domain
Residue E1143
Cluster assignment:
Cluster description:Single Nucleotide Polymorphism
POLG domain:Polymerase domain
Residue M1163
Cluster assignment:
Cluster 1
Cluster description:Polymerase active site and environs
Subcluster:1G (residues 1157-1196)
Subcluster description:Subcluster 1G (residues 1157-1196) maps to a C-terminal region of the palm subdomain, and forms an anti-parallel beta strand adjacent to the Pol A and Pol C motifs (Loh and Loeb, 2005).
POLG domain:Polymerase domain

POLG sequence has amino acid M at position 1163 (not E).

Try query using M1163G

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Type in POLG mutations:
Allele 1:Allele 2:
Allelic information known
Allelic information not known
Example input: A467T T914P
Mutations in the same allele can be separated with a comma
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